USP Apparatus 4 – Flow-Through Dissolution System

Designed to reveal formulation differences that conventional USP Apparatus 1 and 2 might miss, this system is especially effective for poorly soluble drugs, modified/extended release formulations, and low-dose products. With growing relevance in IVIVC (in vitro–in vivo correlation) studies and non-traditional dosage forms, the USP Apparatus 4 continues to evolve, adapting to the dynamic needs of modern pharmaceutical testing.

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USP Apparatus 4 – Flow-Through Dissolution System

Designed to reveal formulation differences that conventional USP Apparatus 1 and 2 might miss, this system is especially effective for poorly soluble drugs, modified/extended release formulations, and low-dose products. With growing relevance in IVIVC (in vitro–in vivo correlation) studies and non-traditional dosage forms, the USP Apparatus 4 continues to evolve, adapting to the dynamic needs of modern pharmaceutical testing.

Intelligent Flow

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Industry-leading piston pump for accurate, pulsation-free flow control
Fully automated media change with programmable selector (up to 3 media + water)
Supports open-loop configuration for high-volume media use
Enables optimal sink conditions without the need for solubilizing agents
Suitable for a wide range of applications:
Parenterals, emulsions, suspensions, microspheres, semi-solids
APIs, powders, granules, tablets, capsules, pellets
Drug-eluting beads, stents, implants, ocular devices, suppositories, softgels
Real-time sampling and automated collection
Simplified, documented workflows for media switching
Engineered for IVIVC studies and pH-dependent drug release profiling
Tool-free maintenance and user-friendly interface
Proven performance in both QC and R&D settings

The system's design supports nearly every dosage form—from standard tablets and capsules to complex drug-eluting implants and semi-solids. Labindia works closely with pharmaceutical innovators to develop custom flow-through cells, optimizing dissolution methods for emerging drug delivery platforms. Whether you're evaluating microspheres, parenterals, or coated ocular devices, the flow-through system adapts to diverse solubility profiles and dosage geometries while ensuring compliance with global pharmacopeial standards.

Enhanced Versatility

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