USP Apparatus 4 – Flow-Through Dissolution System
Designed to reveal formulation differences that conventional USP Apparatus 1 and 2 might miss, this system is especially effective for poorly soluble drugs, modified/extended release formulations, and low-dose products. With growing relevance in IVIVC (in vitro–in vivo correlation) studies and non-traditional dosage forms, the USP Apparatus 4 continues to evolve, adapting to the dynamic needs of modern pharmaceutical testing.
Designed to reveal formulation differences that conventional USP Apparatus 1 and 2 might miss, this system is especially effective for poorly soluble drugs, modified/extended release formulations, and low-dose products. With growing relevance in IVIVC (in vitro–in vivo correlation) studies and non-traditional dosage forms, the USP Apparatus 4 continues to evolve, adapting to the dynamic needs of modern pharmaceutical testing.
At the heart of Labindia’s system is its precision-engineered piston pump, setting a new benchmark in flow-through dissolution testing. Unlike traditional peristaltic pumps, the piston pump ensures ultra-precise and pulsation-free flow, enabling tighter control of flow rates across all test stations. This accuracy is crucial when working with low-dose or extended-release formulations, where even minor fluctuations can affect test outcomes. The robust design reduces wear and maintenance while delivering consistent performance and reproducible results—making it ideal for high-throughput labs and method development environments.
The system's design supports nearly every dosage form—from standard tablets and capsules to complex drug-eluting implants and semi-solids. Labindia works closely with pharmaceutical innovators to develop custom flow-through cells, optimizing dissolution methods for emerging drug delivery platforms. Whether you're evaluating microspheres, parenterals, or coated ocular devices, the flow-through system adapts to diverse solubility profiles and dosage geometries while ensuring compliance with global pharmacopeial standards.